中文English

 

 

1. Cyclopropanation/Ring-opening/Iminium cyclization reaction (CRI reaction) for the total synthesis of complex natural products.

We developed a cascade or stepwise reaction of cyclopropanation/ring-opening/iminium cyclization (the CRI reaction) on tryptamine derivatives to construct three types of indoline alkaloid skeletons: (i) hexahydropyrrolo[2,3-b]indoline (type I), (ii) tetrahydro-9a,4a-iminoethano-9H-carbazole (type II), and (iii) tetrahydroquinolino[2,3-b]indoline (type III). We successfully achieved the total synthesis of structurally intriguing indoline alkaloids such as N-acetylardeemin, minfiensine, vincorine, and communesin F.

 

2. Accomplished Molecules 

 

 

3. Medicinal Chemistry

 

4. Ongoing Total Syntheses